Quantitative analysis in spectroscopy is a crucial technique used to determine the concentration of a specific analyte in a sample. It involves measuring the interaction between matter and electromagnetic radiation, and using this information to quantify the amount of the analyte present. A number of parameters. Quantitative pharmaceutical analysis is nowadays frequently executed using mass spectrometry. Estimation of quantities of substances by mass spectrometry is not straightforward because mass spectrometric measurements are not exactly reproducible (section 1.